:root{
  --bg:#f6f7f8;
  --paper:#ffffff;
  --ink:#0b0d0f;
  --muted:#6c737d;
  --line:#d8dce2;
  --red:#d91919;
  --soft:#eef1f4;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{
  margin:0;background:var(--bg);color:var(--ink);
  font-family:Inter,Arial,Helvetica,sans-serif;
}
a{color:inherit;text-decoration:none}
.topbar{
  position:sticky;top:0;z-index:20;
  display:grid;grid-template-columns:1fr auto auto;align-items:center;gap:28px;
  padding:16px 34px;background:rgba(246,247,248,.92);
  border-bottom:1px solid var(--line);backdrop-filter:blur(14px);
}
.brand{font-weight:900;letter-spacing:-.02em}
.topbar nav{display:flex;gap:20px;font-size:13px;color:#32373d}
.series{font:700 12px/1 monospace;border-left:1px solid var(--line);padding-left:20px}
main{max-width:1440px;margin:auto}
.hero{
  min-height:760px;display:grid;grid-template-columns:.95fr 1.05fr;
  align-items:center;padding:70px 48px 40px;gap:32px;
}
.eyebrow,.section-kicker{
  font:700 11px/1.3 monospace;letter-spacing:.16em;color:var(--muted);text-transform:uppercase
}
h1{font-size:clamp(56px,7vw,110px);line-height:.83;letter-spacing:-.07em;margin:16px 0 20px}
h1 sup{font-size:.23em;vertical-align:top;letter-spacing:0}
.lead{font-size:26px;margin:0 0 14px}
.latin{color:var(--muted);font-size:16px;line-height:1.5}
.warning{
  display:inline-block;margin:24px 0 22px;padding:13px 16px;background:var(--red);
  color:white;font-weight:900;letter-spacing:.02em
}
.hero-actions{display:flex;gap:12px;flex-wrap:wrap}
.button{padding:13px 18px;border:1px solid var(--ink);font-weight:800;font-size:13px}
.button.primary{background:var(--ink);color:white}
.button.ghost:hover{background:white}
.micro{font:12px/1.4 monospace;color:var(--muted);margin-top:20px}
.hero-media img{width:100%;display:block;filter:drop-shadow(0 28px 50px rgba(0,0,0,.12))}
.ticker{
  border-top:1px solid var(--line);border-bottom:1px solid var(--line);
  padding:17px 30px;display:flex;justify-content:center;gap:28px;
  font:800 12px/1 monospace;letter-spacing:.06em;background:#fff
}
.section{padding:90px 48px;border-bottom:1px solid var(--line)}
.grid-2{display:grid;grid-template-columns:1fr 1fr;gap:80px}
h2{font-size:clamp(34px,4vw,64px);line-height:.98;letter-spacing:-.045em;margin:14px 0 0}
.copy{font-size:19px;line-height:1.6;max-width:680px}
.components{
  display:grid;grid-template-columns:repeat(3,1fr);gap:1px;background:var(--line);
  border-bottom:1px solid var(--line);border-top:1px solid var(--line)
}
.components article{background:#fff;padding:36px 34px}
.num{font-size:62px;font-weight:900;letter-spacing:-.08em}
.components h3{font-size:24px;margin:8px 0}
.components p{color:var(--muted)}
.components strong{font:800 13px/1 monospace}
.protocol{display:grid;grid-template-columns:.8fr 1.2fr;gap:40px;align-items:center}
.protocol-image img{width:100%;display:block;border:1px solid var(--line)}
.dose{display:grid;grid-template-columns:repeat(2,1fr);margin:30px 0;border:1px solid var(--line);background:white}
.dose>div{padding:20px;border-right:1px solid var(--line);border-bottom:1px solid var(--line)}
.dose b{display:block;font-size:32px}
.dose span{font:700 11px/1.2 monospace;color:var(--muted)}
.dose .total{background:var(--ink);color:#fff}
.indication-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:1px;background:var(--line);margin-top:34px;border:1px solid var(--line)}
.indication-grid span{background:white;padding:20px;font-size:15px;min-height:86px}
.response blockquote{font-size:32px;line-height:1.2;max-width:900px;margin:42px 0 0;font-weight:700}
.meter{margin-top:36px}
.meter-line{height:18px;background:linear-gradient(90deg,#111 0 32%,#777 32% 68%,var(--red) 68% 100%)}
.meter-labels{display:flex;justify-content:space-between;margin-top:9px;font:700 11px/1 monospace;color:var(--muted)}
.safety{background:#101214;color:#fff}
.safety .section-kicker{color:#aaa}
.safety p{font-size:21px;line-height:1.55;max-width:980px}
.warning.big{font-size:clamp(24px,4vw,58px);line-height:1;padding:18px 20px;margin-top:30px}
.small-note{font-size:13px!important;color:#bbc0c7}
.card.patient{display:flex;align-items:center;justify-content:space-between;gap:30px;background:white}
.seal{
  width:150px;height:150px;border:4px solid var(--red);border-radius:50%;
  display:flex;flex-direction:column;align-items:center;justify-content:center;color:var(--red);
  transform:rotate(-8deg)
}
.seal span{font-size:42px;font-weight:900}
.seal small{font:700 12px monospace}
footer{
  max-width:1440px;margin:auto;padding:30px 48px 60px;display:flex;justify-content:space-between;gap:30px;
  color:var(--muted);font-size:12px
}
.footer-note{text-align:right}
@media(max-width:900px){
  .topbar{grid-template-columns:1fr auto}.topbar nav{display:none}
  .hero,.grid-2,.protocol{grid-template-columns:1fr}
  .hero{padding:50px 20px 20px;min-height:auto}
  .hero-media{order:-1}
  .section{padding:64px 20px}
  .components{grid-template-columns:1fr}
  .indication-grid{grid-template-columns:1fr 1fr}
  .ticker{overflow:auto;justify-content:flex-start}
  footer{padding:28px 20px 50px;flex-direction:column}.footer-note{text-align:left}
}
@media(max-width:560px){
  .indication-grid{grid-template-columns:1fr}
  .dose{grid-template-columns:1fr 1fr}
  .card.patient{align-items:flex-start;flex-direction:column}
}


.history{background:#eef1f4}
.history-head{display:flex;justify-content:space-between;align-items:flex-start;gap:24px;margin-bottom:34px}
.history-sub{font:700 12px/1.4 monospace;color:var(--muted);margin-top:12px}
.history-stamp{border:3px solid var(--red);color:var(--red);font:900 14px/1.05 monospace;padding:12px 16px;transform:rotate(-4deg);text-align:center}
.history-grid{display:grid;grid-template-columns:repeat(2,1fr);gap:14px}
.history-card{background:white;border:1px solid var(--line);padding:24px;min-height:190px}
.history-card.wide{grid-column:1/-1;min-height:auto}
.history-card h3{margin:0 0 16px;font:800 12px/1.2 monospace;text-transform:uppercase;letter-spacing:.08em;color:var(--muted)}
.history-card p{font-size:15px;line-height:1.55;margin:0 0 12px}
.history-card dl{display:grid;grid-template-columns:1.2fr 1fr;gap:8px 16px;margin:18px 0 0;font-size:13px}
.history-card dt{color:var(--muted)}
.history-card dd{margin:0;font-weight:800}
.diagnosis{font:900 28px/1.1 monospace!important;letter-spacing:-.03em}
.treatment{border-left:5px solid var(--red)}
.rxline{display:flex;gap:12px;align-items:baseline;margin-bottom:12px}
.rxline span{font:900 24px/1 serif}
.rxline b{font-size:20px}
@media(max-width:760px){
  .history-grid{grid-template-columns:1fr}
  .history-card.wide{grid-column:auto}
  .history-head{flex-direction:column}
  .history-stamp{align-self:flex-start}
  .history-card dl{grid-template-columns:1fr}
}